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AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a recreational designer drug that acts as a potent. but nonselective full agonist for the cannabinoid receptor.It is part of the AM series of cannabinoids discovered by Alexandros Makriyannis at Northeastern University.
AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a Ki of 1.0 nM at CB1 and 2.6 nM at CB2. The 4-methyl functional analog MAM-2201 probably has similar affinities.[original research? AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptors.AM-2201 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, comparable to the potency of JWH-018 in rats, suggesting potent cannabinoid-like activity
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AM-2201 is a research chemical of the Cannabinoid family. At the Cannabinoid receptor, AM-2201 is a non selective full agonist. Discovered by Alexandros Makriyannis, AM-2201 is part of the AM Series of cannabinoid receptor ligand. AM-2201 is active at extremely low quantities, as low as 0.02g.
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AM-2201 can be used to further research the in vitro (outside living organism) efficacy it has upon the cannabinoid receptors. Due to its non-selectivity, AM-2201 is useful for broad ligand binding assays into the affinity (potency) and duration of action upon receptors. Affinities are: Ki of 1.0nM at CB1 and 2.6nM at CB2. AM-2201 can be combusted using heat to produce a vapour. This vapour is useful as it contains AM-2201 with a high surface area, enabling efficient contact when applied to a membrane containing cannabinoid receptors CB1 and CB2.1-[(5-fluoropentyl)-1H-indol-3- yl]-(naphthalen-1-yl)methanone